期刊
BLOOD CELLS MOLECULES AND DISEASES
卷 36, 期 2, 页码 99-103出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bcmd.2005.12.007
关键词
megakaryocyte; proplatelet; platelet; tubulin; microtubules; dynein; actin; membrane skeleton
类别
Platelets release from megakaryocytes living primarily in the bone marrow space. Intermediates in platelet formation are proplatelets, long tube-like processes that are extended by microtubule-based forces hundreds of micrometers from the megakaryocyte cell body. Granules and organelles enter the proplatelets and traffic up and down on their microtubules to be ultimately delivered to the platelet buds before they release. How individual platelets form and release from proplatelets remains poorly understood. (c) 2006 Elsevier Inc. All rights reserved.
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