4.5 Article

Pterocidin, a cytotoxic compound from the endophytic Streptomyces hygroscopicus

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JOURNAL OF ANTIBIOTICS
卷 59, 期 3, 页码 193-195

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JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/ja.2006.28

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pterocidin; Streptomyces; cytotoxic; delta-lactone

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A new cytotoxic compound, pterocidin, was isolated from the endophytic Streptomyces hygroscopicus TP-A0451, and the structure was determined on the basis of spectroscopic data. Pterocidin showed cytotoxicity against some human cancer cell lines with IC50 values of 2.9 similar to 7.1 mu M.

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