期刊
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
卷 84, 期 3-4, 页码 299-307出版社
NATL RESEARCH COUNCIL CANADA
DOI: 10.1139/Y05-158
关键词
nuclear envelope receptors; angiotensin II; neuropeptide Y; endothelin-1; endocardial endothelial cells; intracellular calcium
资金
- NIDDK NIH HHS [DK41301] Funding Source: Medline
Neuropeptide Y (NPY). endothelin-1 (ET-1). and angiotensin II (Ang II) are peptides that are known to play many important roles in cardiovascular homeostasis. The physiological actions of these peptides are thought to be primarily mediated by plasma membrane receptors that belong to the G-protein-coupled receptor superfamily. However, there is increasing evidence that suggests the existence of functional G-protein-coupled receptors at the level of the nucleus and that the nucleus could be a cell within a cell. Here. we review our work showing the presence in the nucleus of the NPY Y-I receptor. the ETA and ETB receptors, as well as the AT(1) and AT(2) receptors and their respective ligands. This work was carried Out in 20-week-old fetal human endocardial endothelial cells. Our results demonstrate that nuclear Y-I, AT(1), and ETA receptors modulate nuclear calcium in these cells.
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