期刊
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
卷 91, 期 2, 页码 F132-F135出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/adc.2004.068544
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资金
- NHLBI NIH HHS [K08 HL-70711, HL-65397] Funding Source: Medline
- NICHD NIH HHS [HD-12714] Funding Source: Medline
Inflammation interferes with lung development in model systems and is present chronically in the lungs of preterm infants who develop bronchopulmonary dysplasia (BPD). Antenatal inflammation is very commonly associated with preterm deliveries, but there is generally minimal information about the duration, intensity, or organisms associated with chorioamnionitis. In preterm lamb models, chorioamnionitis causes a lung injury similar to BPD and also causes clinical lung maturation. Continuous exposure of the developing lung before and after delivery to inflammation may be central to the development of BPD.
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