期刊
PHYTOMEDICINE
卷 13, 期 4, 页码 284-289出版社
ELSEVIER GMBH
DOI: 10.1016/j.phymed.2004.08.002
关键词
Epilobium angustifolium L.; oenothein B; neutral endopeptidase; angiotensin-converting enzyme; PC-3 cells; prostate cancer; benign prostate hyperplasia
An aqueous extract of Epilobium angustifolium and its main compound oenothein B (OeB), a dimeric macrocyclic ellagitannin, are specifically able to induce the neutral endopeptidase (NEP) in prostate cancer cells. The angiotensin-converting enzyme (ACE) is not influenced. Additionally, a weak but statistically significant inhibition of cell proliferation is observed. Simultaneous treatment of the cells with arabinosylcytosine and the extract as well as the OeB, leads to an additional enhancement of NEP activity. Taking into account the role of this peptidase in prostate cancer progression, our results might offer a pharmacological explanation for the use of Epilobium in folk medicine. (c) 2005 Elsevier GmbH. All rights reserved.
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