期刊
FEMS MICROBIOLOGY LETTERS
卷 256, 期 1, 页码 75-82出版社
OXFORD UNIV PRESS
DOI: 10.1111/j.1574-6968.2006.00105.x
关键词
Leishmania donovani; cell cycle; cyclin-dependent kinase; Cdk-related kinase; Cdk inhibitor
类别
Expression of Leishmania donovani cyclin 1 (LdCyc1) mRNA during the cell cycle of promastigotes is S-phase specific. Here, we show that the LdCyc1 protein is periodically expressed and the activity of its associated kinase varies during the cell cycle in line with its expression pattern. In addition, we have shown that LdCRK3, homologous to CRK3 from L. mexicana, is the cognate Cdk partner of LdCyc1 and that the activity of the complex is inhibited specifically by heat stable factor(s) from the parasite.
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