期刊
JOURNAL OF PROTEOME RESEARCH
卷 5, 期 3, 页码 521-529出版社
AMER CHEMICAL SOC
DOI: 10.1021/pr0502323
关键词
retinal pigment epithelium; melanosome; proteomics
资金
- NCRR NIH HHS [P41 RR11823] Funding Source: Medline
- NEI NIH HHS [R01 EY07042, R01 EY007042-20, EY12598, R01 EY007042] Funding Source: Medline
The protein content of melanosomes in the retinal pigment epithelium (RPE) was analyzed by mass spectrometry. More than 100 proteins were found to be common to two out of three variations of sample preparation. Some proteins normally associated with other organelles were detected. Several lysosornal enzymes were detected, with the presence of cathepsin D confirmed by immunoelectron microscopy, thus supporting the previously suggested notion that melanosomes may contribute to the degradation of ingested photoreceptor outer segment disks.
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