期刊
ANNALS OF THE RHEUMATIC DISEASES
卷 72, 期 7, 页码 1170-1175出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/annrheumdis-2012-201691
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资金
- National Health and Medical Research Council of Australia
- Tasmanian Community Fund
- Masonic Centenary Medical Research Foundation
- Royal Hobart Hospital Research Foundation
- Arthritis Foundation of Australia
Objectives This study describes the longitudinal association between objectively assessed physical activity (PA) and knee structural change measured using MRI. Methods 405 community-dwelling adults aged 51-81 years were measured at baseline and approximately 2.7 years later. MRI of the right knee at baseline and follow-up was performed to evaluate bone marrow lesions (BMLs), meniscal pathology, cartilage defects, and cartilage volume. PA was assessed at baseline by pedometer (steps/day). Results Doing >= 10 000 steps/day was associated with BML increases (RR 1.97, 95% CI 1.19 to 3.27, p=0.009). Participants doing >= 10 000 steps/day had a 1.52 times (95% CI 1.05 to 2.20, p=0.027) greater risk of increasing meniscal pathology score, which increased to 2.49 (95% CI 1.05 to 3.93, p=0.002) in those with adverse meniscal pathology at baseline. Doing >= 10 000 steps/day was associated with a greater risk of increasing cartilage defect score in those with prevalent BMLs at baseline (RR 1.36, 95% CI 1.03 to 1.69, p=0.013). Steps/day was protective against volume loss in those with more baseline cartilage volume but led to increased cartilage loss in those with less baseline cartilage volume. (p=0.046 for interaction). Conclusions PA was deleteriously associated with knee structural change, especially in those with pre-existing knee structural abnormalities. This suggests individuals with knee abnormalities should avoid doing >= 10 000 steps/day. Alternatives to weight-bearing activity may be needed in order to maintain PA levels required for other aspects of health.
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