期刊
MUSCLE & NERVE
卷 33, 期 3, 页码 433-435出版社
WILEY
DOI: 10.1002/mus.20411
关键词
cyclophosphamide; mmune-system rebooting; muscle-specific tyrosine kinase; MuSK antibody; myasthenia gravis; seronegative
We describe a 48-year-old woman with seronegative myasthenia gravis (MG) and high-titer of anti-MuSK antibody. She had severe bulbar and respiratory weakness with minimal limb weakness for 2 years. Her disease responded poorly to all the conventional immunosuppressive regimens. Treatment with immunoablative dose of cyclophosphamide led to dramatic and sustained remission of her symptoms. High-dose cyclophosphamide is an effective alternative in patients with unusually refractory disease.
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