期刊
INFECTION AND IMMUNITY
卷 74, 期 3, 页码 1973-1976出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.74.3.1973-1976.2006
关键词
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A mutant of Brucella suis bearing a Tn5 insertion in norD, the last gene of the operon norEFCBQD, encoding nitric oxide reductase, was unable to survive under anaerobic denitrifying conditions. The norD strain exhibited attenuated multiplication within nitric oxide-producing marine macrophages and rapid elimination in mice, hence demonstrating that norD is essential for Brucella virulence.
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