期刊
IMMUNOLOGY
卷 117, 期 3, 页码 386-395出版社
WILEY
DOI: 10.1111/j.1365-2567.2005.02312.x
关键词
macrophage; peritoneal; suppression; T cell
类别
资金
- NCI NIH HHS [CA77814-01] Funding Source: Medline
- NIAID NIH HHS [AI060356-01, R15 AI060356] Funding Source: Medline
- NIA NIH HHS [R15 AG019631, AG19631-01] Funding Source: Medline
T-lymphocyte activation triggered by anti-CD3, endogenous or exogenous superantigen, and mitogens was suppressed in a cell-dose-dependent fashion by peritoneal cavity (PerC) leucocytes. Study of lymphocyte-deficient mice and the use of multiparameter fluorescence-activated cell sorter analyses revealed that macrophages were responsible for this form of immune regulation. Interferon-gamma was essential to trigger suppression, which, by enzyme inhibition studies, was shown to be the result of tryptophan and arginine catabolism. These results illustrate that macrophages, which are classically defined by their innate effector function as antigen-presenting cells, have the potential to temper adaptive immunity.
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