期刊
AMERICAN JOURNAL OF TRANSPLANTATION
卷 6, 期 3, 页码 505-513出版社
WILEY
DOI: 10.1111/j.1600-6143.2005.01226.x
关键词
costimulation; mouse; NK cells; tolerance; transplantation
资金
- NIAID NIH HHS [R01 AI040310-09, R01 AI 20451, 5R01 AI 052352, R01 AI040310] Funding Source: Medline
- NIGMS NIH HHS [5T32 GM 007281] Funding Source: Medline
To achieve donor-specific immune tolerance to allogeneic organ transplants, it is imperative to understand the cell types involved in acute allograft rejection. In wild-type mice, CD4(+) T cells are necessary and sufficient for acute rejection of cardiac allografts. However, when T-cell responses are suboptimal, such as in mice treated with costimulation-targeting agents or in CD28-deficient mice, and perhaps in transplanted patients taking immunosuppressive drugs, the participation of other lymphocytes such as CD8(+) T cells and NK1.1(+) cells becomes apparent. We found that host NK but not NKT cells were required for cardiac rejection. Ly49G2(+) NK cells suppressed rejection, whereas a subset of NK cells lacking inhibitory Ly49 receptors for donor MHC class I molecules was sufficient to promote rejection. Notably, rejection was independent of the activating receptors Ly49D and NKG2D. Finally, our experiments supported a mechanism by which NK cells promote expansion and effector function of alloreactive T cells. Thus, therapies aimed at specific subsets of NK cells may facilitate transplantation tolerance in settings of impaired T-cell function.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据