期刊
JOURNAL OF FLUORINE CHEMISTRY
卷 127, 期 3, 页码 400-404出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jfluchem.2005.12.034
关键词
difluoromethylation; difluorocarbene; chlorodifluoromethane; fluorinated ether
The reactions of aliphatic fluoro-alcohols with chlorodifluoromethane (CHCIF2) at atmospheric pressure were examined. In the reaction of CF3CF2CH2OH, the difluoromethylated ether was obtained in moderate yield by using ethers such as 1,4-dioxane, diglyme and THF, or their mixtures with water as a reaction solvent. While acetal and orthoformate were also produced, the selectivity of the difluoromethylated ether could be improved by adding water to the reaction. The effect of water could be explained by the reaction mechanism. (c) 2006 Elsevier B.V. All rights reserved.
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