期刊
MEDICINAL RESEARCH REVIEWS
卷 26, 期 2, 页码 131-159出版社
WILEY
DOI: 10.1002/med.20048
关键词
G protein-coupled receptor; adenosine receptor; antagonists
资金
- Intramural NIH HHS [Z01 DK031117-20, ZIA DK031117] Funding Source: Medline
Ever since the discovery of the hypotensive and bradycardiac effects of adenosine, adenosine receptors continue to represent promising drug targets. First, this is due to the fact that the receptors are expressed in a large variety of tissues. In particular, the actions of adenosine (or methylxanthine antagonists) in the central nervous system, in the circulation, on immune cells. and on other tissues can be beneficial in certain disorders. Second, there exists a large number of ligands, which have been generated by introducing several modifications in the structure of the lead compounds (adenosine and methylxanthine), some of them highly specific. Four adenosine receptor subtypes (A(1), A(2A), A(2B), and A(3)) have been cloned and pharmacologically characterized. all of which are G protein-coupled receptors. Adenosine receptors can be distinguished according to their preferred mechanism of signal transduction: A(1) and A(3) receptors interact with pertussis toxin-sensitive G proteins of the G(i) and G(o) family; the canonical signaling mechanism of the A(2A) and of the A(2B) receptors is stimulation of adenylyl cyclase via G, proteins. In addition to the coupling to adenylyl cyclase, all four subtypes may Positively Couple to phospholipase C via different G protein subunits. The development of new ligands, in particular, potent and selective antagonists, for all subtypes of adenosine receptors has so far been directed by traditional medicinal chemistry. The availability of genetic information promises to facilitate understanding of the drug-receptor interaction leading to the rational design of a potentially therapeutically important class of drugs. Moreover, molecular modeling may further rationalize observed interactions between the receptors and their ligands. In this review, we Will summarize the most relevant progress in developing new therapeutic adenosine receptor antagonists. (c) 2005 Wiley Periodicals, Inc.
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