期刊
CLINICAL AND VACCINE IMMUNOLOGY
卷 13, 期 3, 页码 319-328出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/CVI.13.3.319-328.2006
关键词
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资金
- NIDA NIH HHS [R01-DA12366, R01 DA014218, R0-DA14218, R01 DA012366, R01-DA15628, R01 DA015628] Funding Source: Medline
The flavonoids comprise a large class of low-molecular-weight plant metabolites ubiquitously distributed in food plants. These dietary antioxidants exert significant antitumor, antiallergic, and anti-inflammatory effects. The molecular mechanisms of their biological effects remain to be clearly understood. We investigated the anti-inflammatory potentials of a safe, common dietary flavonoid component, quercetin, for its ability to modulate the production and gene expression of the proinflammatory cytokine tumor necrosis factor alpha (TNF-alpha) by human peripheral blood mononuclear cells (PBMC). Our results showed that quercetin significantly inhibited TNF-alpha production and gene expression in a dose-dependent manner. Our results provide direct evidence of the anti-inflammatory effects of quercetin by PBMC, which are mediated by the inhibition of the proinflammatory cytokine TNF-alpha via modulation of NF-kappa beta 1 and I kappa beta.
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