期刊
JOURNAL OF APPLIED PHYSIOLOGY
卷 100, 期 3, 页码 981-987出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/japplphysiol.00831.2005
关键词
compensatory overload; heat shock proteins; fiber types; thyroid hormone; fiber transformation
Heat shock protein 72 ( Hsp70) is constitutively expressed in rat hindlimb muscles, reportedly in proportion to their content of type I myosin heavy chain. This distribution pattern has been suggested to result from the higher recruitment and activity of such muscles and/or a specific relationship between myosin phenotype and Hsp70 content. To differentiate between these possibilities, the fiber-specific distribution of Hsp70 was examined in male Sprague- Dawley rat plantaris under control conditions, following a fast-to-slow phenotypic shift in response to surgically induced overload ( O) and in response to O when the phenotypic shift was prevented by 3,5,3'-triiodo-(DL)-thyronine administration. Constitutive expression of Hsp70 was restricted to type I and IIa fibers in plantaris from control rats, and this fiber- specific pattern of expression was maintained following O of up to 28 days, although Hsp70 content in the O muscle doubled. When O ( for 40 days) of the plantaris was combined with 3,5,3'-triiodo-(DL)-thyronine administration, despite typical hypertrophy in the overloaded plantaris, prevention of the normal phenotypic transformation also blocked the increased expression of Hsp70 observed in euthyroid controls. Collectively, these data suggest that chronic changes in constitutive expression of Hsp70 with altered contractile activity appear critically dependent on fast-to-slow phenotypic remodeling.
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