期刊
ANNALS OF THE RHEUMATIC DISEASES
卷 69, 期 11, 页码 1898-1906出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/ard.2010.134684
关键词
-
类别
资金
- NIH
- Wellcome Trust
- MRC (UK)
- Arthritis Research UK
- Pfizer
- Roche
- Schering Plough
- BMS
The understanding of the pathogenesis and optimal therapeutics for rheumatoid arthritis (RA) has advanced remarkably over the last decade. This review highlights these key advances, particularly the outcomes of genome-wide scans which have provided an increasingly robust appraisal of the complex genetics that underpin RA. Such observations are placed in pathogenetic context, particularly concerning the breach of tolerance that presages synovitis and the mechanisms that subserve chronicity. The key therapeutic strategies and treatment agents, both conventional and biological, now available to effectively manage the disease are described. Throughout the review, emphasis is placed on unanswered questions and challenges in this exciting field.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据