期刊
EPILEPSIA
卷 47, 期 3, 页码 495-498出版社
BLACKWELL PUBLISHING
DOI: 10.1111/j.1528-1167.2006.00457.x
关键词
gamma-aminobutyric acid; homocarnosine; human epilepsy; gabapentin; topiramate; H-1 nuclear magnetic resonance spectroscopy; brain
资金
- NINDS NIH HHS [R01-NS032518, R01-NS37527, P01-NS06208] Funding Source: Medline
Purpose: To assess the relation between seizure control and brain homocarnosine and gamma-aminobutyric acid (GABA) levels of patients with complex partial seizures taking gabapentin (GBP) or topiramate (TPM) as adjunctive therapy. Methods: In vivo measurements of GABA and homocarnosine were made of a 14-cc volume in the occipital cortex by using H-1 spectroscopy with a 2.1-Tesla magnetic resonance spectrometer and an 8-cm surface coil. Poor seizure control was defined as more recent seizures than the median for the two groups of patients studied. Results: Homocarnosine levels were higher in patients with better seizure control than in those with poor control. No differences were found in the intracellular GABA levels between the patients who responded to GBP or TPM compared with those who did not. Conclusions: In the visual neocortex, which is remote from the presumed seizure-onset zone, higher homocarnosine levels were associated with better seizure control in the patients taking GBP or TPM as adjunctive therapy; elevated intracellular GABA levels appeared to offer no additional protection.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据