期刊
INTERNATIONAL JOURNAL OF OBESITY
卷 30, 期 3, 页码 552-560出版社
SPRINGERNATURE
DOI: 10.1038/sj.ijo.0803186
关键词
blood lipids; lipoprotein-cholesterol; drop-out rate; low-carbohydrate diet
Objective: To investigate whether a hypo-energetic low-fat diet is superior to a hypo-energetic high-fat diet for the treatment of obesity. Design: Open-label, 10-week dietary intervention comparing two hypo-energetic ( -600 kcal/day) diets with a fat energy percent of 20-25 or 40-45. Subjects: Obese ( BMI >= 30 kg/m(2)) adult subjects ( n = 771), from eight European centers. Measurements: Body weight loss, dropout rates, proportion of subjects who lost more than 10% of initial body weight, blood lipid profile, insulin and glucose. Results: The dietary fat energy percent was 25% in the low-fat group and 40% in the high-fat group ( mean difference: 16 ( 95% confidence interval ( CI) 15-17)%). Average weight loss was 6.9 kg in the low-fat group and 6.6 kg in the high-fat group ( mean difference: 0.3 ( 95% CI-0.2 to 0.8) kg). Dropout was 13.6% (n = 53) in the low-fat group and 18.3% ( n 70) in the high-fat group ( P = 0.001). Among completers, more subjects lost > 10% in the low-fat group than in the high-fat group (( 20.8%, n = 70) versus ( 14.7%, n = 46), P = 0.02). Fasting plasma total, low-density lipoprotein- and high-density lipoprotein-cholesterol decreased in both groups, but more so in the low-fat group than in the high-fat group. Fasting plasma insulin and glucose were lowered equally by both diets. Conclusions: The low-fat diet produced similar mean weight loss as the high-fat diet, but resulted in more subjects losing > 10% of initial body weight and fewer dropouts. Both diets produced favorable changes in fasting blood lipids, insulin and glucose.
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