期刊
ANNALS OF THE RHEUMATIC DISEASES
卷 69, 期 1, 页码 210-213出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/ard.2008.105254
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资金
- Fundacion Espanola de Reumatologia (Proyecto GEN-SER), Instituto de Salud Carlos III [FIS: PI-082028]
- Secretaria I+D+I Xunta de Galicia [PGIDIT06PXIC916175PN]
- Fondo Investigacion Sanitaria [CIBER-BBN CB06/01/0040]
- (FEDER) European Community
- Contrato de Apoyo a la Investigacion-Fondo Investigacion Sanitaria [CA06/01102]
Objective: To analyse the mitochondrial DNA (mtDNA) haplogroups of patients with hip osteoarthritis (OA) and those of healthy controls in a Spanish population. Methods: mtDNA haplogroups were assigned to 550 cases of hip OA and 505 clinically asymptomatic controls. Sets of controls with healthy knees and hips (n = 179) and patients with knee and/or hip OA (n = 977) were also analysed in a multivariate analysis after adjusting for sex, age and smoking. Results: Individuals carrying haplogroup J showed a significantly decreased risk of developing hip OA (OR 0.661; 95% CI 0.440 to 0.993; p = 0.045). In addition to haplogroup J, smoking protected against the development of hip OA (OR 0.543; 95% CI 0.311 to 0.946; p = 0.031). However, no relationship was found between rheumatoid arthritis and mtDNA haplogroups. Conclusion: The results of this study support the hypothesis that the mtDNA haplogroups have a role in the complex osteoarthritic process.
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