期刊
MICROBES AND INFECTION
卷 8, 期 3, 页码 938-945出版社
ELSEVIER
DOI: 10.1016/j.micinf.2005.09.005
关键词
glycolipid depletion therapy; pathogen binding to decoys; protective adhesin therapy; receptors and ligands; HIV-1
The binding of many pathogens and toxins to human cells can be inhibited by (1) depleting host cells of their surface glycosphingolipids; (2) coating the binding sites on pathogens (adhesins) with glycosphingolipid-like substances (decoys); (3) coating the host's glycosphingolipids with substances that compete with the pathogen for binding. Details of using these methods are described. (c) 2005 Elsevier SAS. All rights reserved.
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