期刊
ANNALS OF THE RHEUMATIC DISEASES
卷 69, 期 6, 页码 1235-1238出版社
B M J PUBLISHING GROUP
DOI: 10.1136/ard.2009.118158
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资金
- Faculty of Medicine and Dentistry at the University of Bergen
- Strategic Research Program at Helse Bergen
- Western Norway Regional Health Authority
- Broegelmann Foundation
- Norwegian Cancer Society
- Bergen Research Foundation
Objective Sjogren's syndrome (SS) is a lymphoproliferative autoimmune disease, characterised by dryness of the mouth and eyes. Dendritic cells (DC) are potent antigen-presenting cells crucial for initiating and maintaining primary immune responses. This study quantified interferon-producing plasmacytoid DC (pDC) and two myeloid DC subsets (mDC1 and mDC2) in peripheral blood (PB) from primary SS (pSS) patients and healthy controls. Methods Blood samples from 31 pSS patients and 28 gender and age-matched healthy controls were analysed by flow cytometry using the Miltenyi Blood DC enumeration kit. The presence of pDC in salivary glands (SG) from pSS patients was analysed by immunohistochemistry. Results Patients with pSS had significantly less pDC and mDC2 in PB compared with healthy controls. Moreover, pDC are present in SG from patients with pSS. Conclusion Patients with pSS have alterations among DC populations in PB, and pDC are present in the SG, suggesting a potential role of these cells in SS.
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