Swelling and hydrolytic degradation of poly(D,L-lactic acid) in aqueous solutions

Low molecular weight poly(lactic acid) was synthesized by direct polycondensation of lactic acid. The oligomers were characterized by viscometry, light scattering, and gel permeation chromatography (GPC). The swelling behaviour of tablets made of the above polymer immersed in buffer solutions at 37 degrees C was studied. In the same experiments, the hydrolytic stability of D,L-PLA was assessed by measuring the weight loss after drying the tablets. In order to inhibit any degradation due to bacteria, formaldehyde was added in the solution as biostatic factor. The effect of an incorporated drug on the swelling behaviour Of D,L-PLA tablets was also considered. It was found that the incorporation of drug in D,L-PLA tablets increases their swelling index, probably due to the creation of additional porosity in the specimens or other interaction between drug and polymeric matrix. (c) 2005 Elsevier Ltd. All rights reserved.