期刊
EXPERIMENTAL GERONTOLOGY
卷 41, 期 3, 页码 282-288出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2005.11.008
关键词
aging; hypertension; endothelin receptors; insulin
In the present paper, the age-related changes in the vasoconstrictive endothelia-mediated response to insulin in aortas of normal and hypertensive, hypertriglyceridemic, hyperinsulinemic (HTG) rats were studied. To develop HTG rats, weanling male Wistar animals were given 30% sucrose in their drinking water for 4, 6, 12 and 18 months. Blood pressure was increased in HTG rats for up to 12 months showing a maximum at 6 months (138.9 +/- 0.8 mm Hg). In vitro contractions were elicited with 40 mM KCl in the presence and absence 50 mu U/ml insulin and of endothelia-receptor antagonists BQ123 and BQ788. Tension development to KCl was not modified during aging in control rats but was increased at 4 and 6 months in HTG rats. Increased endothelin release induced by insulin remained constant in normal rats, while in HTG rats it was higher than in controls at all ages. ETA blocker participation alone increased during aging in control rats while both receptor blockers participated in HTG rats. Our results suggest that the vasoconstrictive capacity to KCl plus insulin decreases during aging and that this decrease is greater in HTG rats. The participation of endothelia receptors in the aging process differs in control and HTG rats. (c) 2005 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据