期刊
YEAR IN DIABETES AND OBESITY
卷 1311, 期 -, 页码 14-30出版社
BLACKWELL SCIENCE PUBL
DOI: 10.1111/nyas.12327
关键词
lipodystrophy; marrow fat; osteoporosis; diabetes; marrow adipose tissue
资金
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [T32DE007057, K99DE024178] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R24DK092759, R24DK084970] Funding Source: NIH RePORTER
- NIDCR NIH HHS [T32 DE007057, K99 DE024178] Funding Source: Medline
- NIDDK NIH HHS [R24 DK092759, R24 DK084970] Funding Source: Medline
Marrow adipose tissue ( MAT) is functionally distinct from both white and brown adipose tissue and can contribute to systemic and skeletal metabolism. MAT formation is a spatially and temporally defined developmental event, suggesting that MAT is an organ that serves important functions and, like other organs, can undergo pathologic change. The well-documented inverse relationship between MAT and bone mineral density has been interpreted to mean that MAT removal is a possible therapeutic target for osteoporosis. However, the bone and metabolic phenotypes of patients with lipodystrophy argues that retention of MAT may actually be beneficial in some circumstances. Furthermore, MAT may exist in two forms, regulated and constitutive, with divergent responses to hematopoietic and nutritional demands. In this review, we discuss the role of MAT in lipodystrophy, bone loss, and metabolism, and highlight our current understanding of this unique adipose tissue depot.
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