期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 14, 期 5, 页码 1497-1505出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2005.10.002
关键词
substituted phenanthrenes; anti-breast cancer agents; basic amino side chain
In the course of our search for new anti-breast cancer agents, substituted phenanthrenes with basic amino side chains were synthesized and some of them showed remarkable antiproliferative activity against ER +ve MCF-7 cell line with IC50 in the range of 3.53-22.25 mu M. One of the compounds 15ca showed anti-breast cancer activity in 7,12-dimethylbenz[a]anthracene (DMBA) induced hormone-dependent mammary tumor in rat and the activity was comparable to that shown by tamoxifen. (c) 2005 Elsevier Ltd. All rights reserved.
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