期刊
YEAR IN COGNITIVE NEUROSCIENCE
卷 1316, 期 -, 页码 53-70出版社
BLACKWELL SCIENCE PUBL
DOI: 10.1111/nyas.12415
关键词
insula; addiction; risk; craving; drug seeking
资金
- NIAAA NIH HHS [K23 AA022771] Funding Source: Medline
- NIDA NIH HHS [T32 DA007294, R21 DA016708, F30 DA016847, R01 DA16708] Funding Source: Medline
- NIGMS NIH HHS [T32 GM007337] Funding Source: Medline
- NIMH NIH HHS [T32 MH020004] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM007337] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [T32MH020004, R25MH086466] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [K23AA022771] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [T32DA007294, F30DA016847, R21DA016708] Funding Source: NIH RePORTER
Drug addiction is characterized by the inability to control drug use when it results in negative consequences or conflicts with more adaptive goals. Our previous work showed that damage to the insula disrupted addiction to cigarette smoking-the first time that the insula was shown to be a critical neural substrate for addiction. Here, we review those findings, as well as more recent studies that corroborate and extend them, demonstrating the role of the insula in (1) incentive motivational processes that drive addictive behavior, (2) control processes that moderate or inhibit addictive behavior, and (3) interoceptive processes that represent bodily states associated with drug use. We then describe a theoretical framework that attempts to integrate these seemingly disparate findings. In this framework, the insula functions in the recall of interoceptive drug effects during craving and drug seeking under specific conditions where drug taking is perceived as risky and/or where there is conflict between drug taking and more adaptive goals. We describe this framework in an evolutionary context and discuss its implications for understanding the mechanisms of behavior change in addiction treatments.
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