期刊
RENAISSANCE OF CANCER IMMUNOTHERAPY
卷 1284, 期 -, 页码 46-51出版社
BLACKWELL SCIENCE PUBL
DOI: 10.1111/nyas.12114
关键词
dendritic cells; immunotherapy; NF-kappa B
资金
- Canada Research Chair in Autoimmunity and Tumor Immunity
Dendritic cells are master regulators of immunity. Immature dendritic cells are essential for maintaining selftolerance, while mature dendritic cells initiate a variety of specialized immune responses. Dendritic cell quiescence is often viewed as a default state that requires exogenous stimuli to induce maturation. However, recent studies have identified dendritic cell quiescence factors that actively program dendritic cells to an immature state. In the absence of these factors, dendritic cells spontaneously become immunogenic and can induce autoimmune responses. Herein we discuss two such factors, NF-kappa B1 and A20, that preserve dendritic cell immaturity through their regulation of NF-kappa B signaling. Loss of either of these factors increases dendritic cell immunogenicity, suggesting that they may be important targets for enhancing dendritic cell-based cancer immunotherapies. Alternatively, defects in molecules critical for maintaining steady-state DCs may provide novel biomarkers that identify patients who have enhanced natural antitumor immunity or that correlate with better responses to various immunotherapies.
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