期刊
RESVERATROL AND HEALTH
卷 1290, 期 -, 页码 130-135出版社
BLACKWELL SCIENCE PUBL
DOI: 10.1111/nyas.12216
关键词
resveratrol; myocardial ischemia; pig model; cardiovascular disease; metabolic syndrome
Resveratrol is a naturally occurring polyphenol found in the skin of red grapes, peanuts, and red wine that has been shown to modify many cardiovascular risk factors. Small animal models have been extensively used to investigate cardiovascular disease, but the results often fail to translate in clinical trials. Disease-specific pig models are emerging as clinically useful tools that may offer insight into cardiovascular disease and the effect of drugs such as resveratrol on cardiovascular health. In this paper, we discuss the advantage of using clinically relevant pig models of diabetes, hypercholesterolemia, and myocardial ischemia to investigate the role of resveratrol in cardiovascular disease prevention.
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