期刊
CLINICAL SCIENCE
卷 110, 期 3, 页码 293-304出版社
PORTLAND PRESS LTD
DOI: 10.1042/CS20050178
关键词
apoptosis; cosinophil; granulocyte; inflammation; lung disease; neutrophil
资金
- MRC [G108/595, G116/170] Funding Source: UKRI
- Medical Research Council [G108/595, G116/170] Funding Source: researchfish
- Medical Research Council [G116/170, G108/595] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
Apoptosis, programmed cell death, of neutrophil and eosinophil granulocytes is a potential control point in the physiological resolution of innate immune responses. There is also increasing evidence that cellular processes of apoptosis can be dysregulated by pathogens as a mechanism of immune evasion and that delayed apoptosis, resulting in prolonged inflammatory cell survival, is important in persistence of tissue inflammation. The identification of cell-type specific pathways to apoptosis may allow the design of novel anti-inflammatory therapies or agents to augment the innate immune responses to infection. This review will explore the physiological roles of granulocyte apoptosis and their importance in infectious and non-infectious lung disease.
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