期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 16, 期 5, 页码 1380-1383出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2005.11.045
关键词
protoberberine derivatives; hypoglycemic effect; cell membrane chromatography
Various berberine derivatives (2-17) were synthesized and their antihyperglycemic activities were evaluated in a model of beta-cell-membrane chromatography and a model of alloxan-induced diabetes mice. The results indicated that compounds 5 and 14 exhibited antihyperglycemic activity. Their structure-activity relationships were discussed. (C) 2005 Elsevier Ltd. All rights reserved.
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