期刊
CELL CYCLE
卷 5, 期 5, 页码 512-518出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.5.5.2538
关键词
Akt signaling; angiogenesis; endothelial cell; thrombospondin; collagen; laminin; vascular permeability
类别
资金
- NHLBI NIH HHS [R01 HL071625, HL071625] Funding Source: Medline
Akt, also known as Protein kinase B (PKB), regulates essential cellular functions such as migration, proliferation, differentiation, apoptosis, and metabolism. Akt influences the expression and/or activity of various pro- and anti-angiogenic factors and Akt isoforms (Akt1, Akt2 and Akt3) have been proposed as therapeutic targets for angiogenesis-related anomalies such as cancer and ischemic injury.
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