期刊
BARRIERS AND CHANNELS FORMED BY TIGHT JUNCTION PROTEINS I
卷 1257, 期 -, 页码 77-84出版社
BLACKWELL SCIENCE PUBL
DOI: 10.1111/j.1749-6632.2012.06528.x
关键词
tight junction; FRAP; claudin; occludin; ZO-1
资金
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [K08DK088953] Funding Source: NIH RePORTER
- NIDDK NIH HHS [K08 DK088953] Funding Source: Medline
A principal role of tight junctions is to seal the apical intercellular space and limit paracellular flux of ions and molecules. Despite the fact that tight junctions form heavily cross-linked structures, functional studies have fostered the hypothesis that the tight junction barrier is dynamic and defined by opening and closing events. However, it has been impossible to directly measure tight junction barrier function with sufficient resolution to detect such events. Nevertheless, recent electrophysiological and sieving studies have provided tremendous insight into the presence of at least two pathways of trans-tight junction flux: a high-capacity ion-selective pore pathway and a low-capacity leak pathway that allows the passage of macromolecules. Furthermore, it is now known that the tight junction molecular structure is highly dynamic and that dynamics are correlated with barrier function. Taken together, these data support a dynamic model of tight junction conductance and suggest that regulation of tight junction openings and closings may provide sensitive means of barrier regulation.
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