期刊
BARRIERS AND CHANNELS FORMED BY TIGHT JUNCTION PROTEINS II
卷 1258, 期 -, 页码 65-70出版社
BLACKWELL SCIENCE PUBL
DOI: 10.1111/j.1749-6632.2012.06503.x
关键词
Clostridium perfringens enterotoxin; claudin; mucosal absorption; cancer-targeting; vaccination
Claudins (CLs) are a family of tetra-integralmembrane proteins that are a key structural and functional component of tight junctions. CLs are overexpressed in somemalignant tumors. Claudin-4 is highly expressed in the epithelial cells covering mucosal immune tissues. CLs may therefore be a potential target for improving drug absorption, treating cancer, and developing mucosal vaccine. Research using Clostridium perfringens enterotoxin has resulted in proofs of concept for CL-targeted drug development. A platform for the creation of CL binders, such as immunization of CL and preparation of CL proteins, is now beginning to be established.
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