期刊
EFFECTS OF GENOME STRUCTURE AND SEQUENCE ON VARIATION AND EVOLUTION
卷 1267, 期 -, 页码 61-70出版社
BLACKWELL SCIENCE PUBL
DOI: 10.1111/j.1749-6632.2012.06603.x
关键词
venom peptides; accelerated evolution; Conidae; Turridae
资金
- FIC NIH HHS [1U01TW008163, U01 TW008163, U19 TW008163] Funding Source: Medline
- NIGMS NIH HHS [GM48677, P01 GM048677] Funding Source: Medline
- FOGARTY INTERNATIONAL CENTER [U01TW008163] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P01GM048677] Funding Source: NIH RePORTER
An impressive biodiversity (>10,000 species) of marine snails (suborder Toxoglossa or superfamily Conoidea) have complex venoms, each containing approximately 100 biologically active, disulfide-rich peptides. In the genus Conus, the most intensively investigated toxoglossan lineage (similar to 500 species), a small set of venom gene superfamilies undergo rapid sequence hyperdiversification within their mature toxin regions. Each major lineage of Toxoglossa has its own distinct set of venom gene superfamilies. Two recently identified venom gene superfamilies are expressed in the large Turridae clade, but not in Conus. Thus, as major venomous molluscan clades expand, a small set of lineage-specific venom gene superfamilies undergo accelerated evolution. The juxtaposition of extremely conserved signal sequences with hypervariable mature peptide regions is unprecedented and raises the possibility that in these gene superfamilies, the signal sequences are conserved as a result of an essential role they play in enabling rapid sequence evolution of the region of the gene that encodes the active toxin.
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