期刊
THYMOSINS IN HEALTH AND DISEASE I
卷 1269, 期 -, 页码 26-33出版社
BLACKWELL SCIENCE PUBL
DOI: 10.1111/j.1749-6632.2012.06697.x
关键词
thymosin alpha 1; cancer; immune effector cells; tumor antigens
资金
- Italian Ministry of University and Research (MIUR)
- MIUR [Prot. 10484, Prot. 1558]
Since it was first identified, thymosin alpha 1 (T alpha 1) has been characterized to have pleiotropic effects on several pathological conditions, in particular as a modulator of immune response and inflammation. Several properties exerted by T alpha 1 may be attributable to a direct action on lymphoid cells. T alpha 1 has been shown to exert an immune modulatory activity on both T cell and natural killer cell maturation and to have an effect on functions of mature lymphocytes, including stimulating cytokine production and cytotoxic T lymphocyte-mediated cytotoxic responses. In previous studies we have shown that T alpha 1 increases the expression of major histocompatibility complex class I surface molecules in murine and human tumor cell lines and in primary cultures of human macrophages. In the present paper, we describe preliminary data indicating that T alpha 1 is also capable of increasing the expression of tumor antigens in both experimental and human tumor cell lines. This effect, which is exerted at the level of the target tumor cells, represents an additional factor increasing the antitumor activity of T alpha 1.
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