期刊
ADVANCES AGAINST ASPERGILLOSIS II
卷 1273, 期 -, 页码 18-24出版社
BLACKWELL SCIENCE PUBL
DOI: 10.1111/j.1749-6632.2012.06822.x
关键词
Aspergillus; resistance; molecular identification
类别
资金
- REIPI (Red Espanola de Investigacion en Patologia Infecciosa [MPY 1022/07_1]
- Instituto de Salud Carlos III
- European Development Regional Fund A way to achieve Europe ERDF, Spanish Network for the Research in Infectious Diseases [REIPI RD06/0008]
- Astellas Pharma
- BioMerieux
- Gilead Sciences
- Merck Sharp and Dohme
- Pfizer
- Schering Plough
- Soria Melguizo SA
- Ferrer International
- European Union
- ALBAN program
- Spanish Agency for International Cooperation
- Spanish Ministry of Culture and Education
- Spanish Health Research Fund
- Ramon Areces Foundation
- The Mutua Madrilena Foundation
The identification of fungi by molecular techniques has generated important changes in fungal taxonomy. The use of molecular tools in taxonomic studies has led to the description of some cryptic species that were placed into a complex of morphologically similar organisms and were subsequently misidentified. There are still limited data available on the prevalence of cryptic species of Aspergillus in the clinical setting, although some studies report 10-14% of the total number of Aspergillus species. In addition, the main concern about the emergence of Aspergillus cryptic species is that they can be more resistant to antifungal agents. The rise in the incidence of fungal infections and the changing landscape of epidemiology, together with the description of new pathogens and their different susceptibility profiles, make the identification by molecular methods and/or antifungal susceptibility testing the best options available for the correct management of these infections.
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