期刊
EVOLVING CHALLENGES IN PROMOTING CARDIOVASCULAR HEALTH
卷 1254, 期 -, 页码 82-89出版社
BLACKWELL SCIENCE PUBL
DOI: 10.1111/j.1749-6632.2012.06487.x
关键词
bioenergetics; glycolysis; oxidative metabolism; regenerative medicine; induced pluripotent stem cells; embryonic stem cells; lineage specification
资金
- National Institutes of Health
- Canadian Institutes of Health Research
- Marriott Foundation
- Mayo Clinic
Engineering pluripotency through nuclear reprogramming and directing stem cells into defined lineages underscores cell fate plasticity. Acquisition of and departure from stemness are governed by genetic and epigenetic controllers, with modulation of energy metabolism and associated signaling increasingly implicated in cell identity determination. Transition from oxidative metabolism, typical of somatic tissues, into glycolysis is a prerequisite to fuel-proficient reprogramming, directing a differentiated cytotype back to the pluripotent state. The glycolytic metabotype supports the anabolic and catabolic requirements of pluripotent cell homeostasis. Conversely, redirection of pluripotency into defined lineages requires mitochondrial biogenesis and maturation of efficient oxidative energy generation and distribution networks to match demands. The vital function of bioenergetics in regulating stemness and lineage specification implicates a broader role for metabolic reprogramming in cell fate decisions and determinations of tissue regenerative potential.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据