期刊
BRAIN STIMULATION IN NEUROLOGY AND PSYCHIATRY
卷 1265, 期 -, 页码 9-24出版社
BLACKWELL SCIENCE PUBL
DOI: 10.1111/j.1749-6632.2012.06650.x
关键词
Parkinson's; DBS; feedback control; LFP; beta
资金
- MRC [G0901503] Funding Source: UKRI
- Medical Research Council [G0901503] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
Feedback control of deep brain stimulation (DBS) in Parkinson's disease has great potential to improve efficacy, reduce side effects, and decrease the cost of treatment. In this, the timing and intensity of stimulation are titrated according to biomarkers that capture current clinical state. Stimulation may be at standard high frequency or intelligently patterned to directly modify specific pathological rhythms. The search for and validation of appropriate feedback signals are therefore crucial. Signals recorded from the DBS electrode currently appear to be the most promising source of feedback. In particular, beta-frequency band oscillations in the local field potential recorded at the stimulation target may capture variation in bradykinesia and rigidity across patients, but this remains to be confirmed within patients. Biomarkers that reliably reflect other impairments, such as tremor, also need to be established. Finally, whether brain signals are causally important needs to be established before stimulation can be specifically patterned rather than delivered at empirically defined high frequency.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据