期刊
GLYCOBIOLOGY OF THE IMMUNE RESPONSE
卷 1253, 期 -, 页码 68-79出版社
BLACKWELL SCIENCE PUBL
DOI: 10.1111/j.1749-6632.2011.06435.x
关键词
microbial infection; immune responses; glycolipid antigens; CD1; NKT cells
资金
- NIAID NIH HHS [AI71922, AI69296, R01 AI045053-10, R37 AI071922-20, R01 AI074952, R37 AI071922, R01 AI074952-04, R01 AI045053, R37 AI071922-19, R01 AI074952-03, R01 AI069296-05, AI45053, AI74952, R01 AI069296, R56 AI074952] Funding Source: Medline
Natural killer T (NKT) cells are a T cell subpopulation that were named originally based on coexpression of receptors found on natural killer (NK) cells, cells of the innate immune system, and by T lymphocytes. The maturation and activation of NKT cells requires presentation of glycolipid antigens by CD1d, a cell surface protein distantly related to the major histocompatibility complex (MHC)-encoded antigen presenting molecules. This specificity distinguishes NKT cells from most CD4(+) and CD8(+) T cells that recognize peptides presented by MHC class I and class II molecules. The rapid secretion of a large amount of both Th1 and Th2 cytokines by activated NKT cells endows them with the ability to play a vital role in the host immune defense against various microbial infections. In this review, we summarize progress on identifying the sources of microbe-derived glycolipid antigens recognized by NKT cells and the biochemical basis for their recognition.
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