期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 16, 期 5, 页码 1397-1401出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2005.11.039
关键词
c-Jun N-terminal kinase-3; JNK3 inhibitors; 2 '-anilino-4,4 '-bipyridines; structure based design; structure-activity relationship
The design and synthesis of a new series of c-Jun N-terminal kinase-3 (JNK3) inhibitors with selectivity against JNK1 are reported. The novel series of substituted 2'-anilino-4,4'-bipyridines were designed based on a combination of hits from high throughput screening and X-ray crystal structure information of compounds crystallized into the JNK3 ATP binding active site. (C) 2005 Elsevier Ltd. All rights reserved.
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