期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
卷 1758, 期 3, 页码 290-300出版社
ELSEVIER
DOI: 10.1016/j.bbamem.2005.10.013
关键词
oligonucleotide; siRNA; HIV-1; AIDS; virucide; antiviral agent
资金
- Medical Research Council [MC_U105178803] Funding Source: Medline
- MRC [MC_U105178803] Funding Source: UKRI
- Medical Research Council [MC_U105178803] Funding Source: researchfish
New candidates for development as potential drugs or virucides against HIV-1 infection and AIDS continue to be needed. The HIV-1 RNA leader sequence has many essential functional sites for virus replication and regulation that includes several highly conserved sequences. The review describes the historical context of targeting the HIV-1 RNA leader sequence with antisense phosphorothioate oligonucleotides, such as GEM 91, and goes on to describe modem approaches to targeting this region with steric blocking oligonucleotide analogues having newer and more advantageous chemistries, as well as recent studies on siRNA, towards the attainment of antiviral activity. Recent attempts to obtain improved cell delivery are highlighted, including exciting new developments in the use of peptide conjugates of peptide nucleic acid (PNA) as potential virucides. (c) 2005 Elsevier B.V. All rights reserved.
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