期刊
ADDICTION REVIEWS
卷 1216, 期 -, 页码 99-113出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2010.05893.x
关键词
histone; chromatin; plasticity; histone deacetylase (HDAC); histone methyltransferase (HMT); drug addiction
资金
- NATIONAL INSTITUTE ON DRUG ABUSE [P01DA008227, R01DA007359, R37DA007359] Funding Source: NIH RePORTER
- NIDA NIH HHS [R01 DA007359, R01 DA007359-24, P01 DA008227-19, R01 DA007359-23, P01 DA008227, P01 DA008227-20] Funding Source: Medline
Drug-induced alterations in gene expression throughout the reward circuitry of the brain are likely components of the persistence of the drug-addicted state. Recent studies examining the molecular mechanisms controlling drug-induced transcriptional, behavioral, and synaptic plasticity have indicated a direct role for chromatin remodeling in the regulation and stability of drug-mediated neuronal gene programs, and the subsequent promulgation of addictive behaviors. In this review, we discuss recent advances in our understanding of chromatin phenomena-or epigenetics, by one definition-that contribute to drug addiction, with the hope that such mechanistic insights may aid in the development of novel therapeutics for future treatments of addiction.
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