期刊
CLINICAL MEDICINE & RESEARCH
卷 4, 期 1, 页码 7-11出版社
MARSHFIELD CLINIC
DOI: 10.3121/cmr.4.1.7
关键词
CAMP strains; Erythrocyte binding antigen 175 kDa; FCR-3 strains; Plasmodium falciparum
资金
- Government of Gabon
- Total-Fina-Elf Gabon
- Ministere Francais des Affaires Etrangeres
Objective: The erythrocyte binding antigen 175 kDa (EBA-175) of Plasmodium falciparum is one of the major ligands for red blood cell invasion by merozoites. EBA-175 is a dimorphic antigen but the role that dimorphism plays in host parasite interaction is not fully understood. In this study, we sought to determine the distribution of EBA-175 genotypes and its pathogenetic influence Methods: The nested polymerase chain reaction was used to determine the genotypes of P.falciparum isolates from asymptomatic and symptomatic Gabonese children Results: CAMP strains (C-segment) and FCR-3 strains (F-segment) were found in 13/50 (26%) and 19/50 (38%) symptomatic children, respectively and in 16/66 (24%) and 46/66 (70%) asymptomatic children, respectively. The prevalence of mixed C-/F-infection was 18/50 (36%) and 4/66 (6%) in symptomatic and asymptomatic children, respectively Conclusions: These results show that mixed C-/F-infection is associated with clinical malaria (chi(2), P < 0.01) and may have important therapeutic implications
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