期刊
NUTRITION AND PHYSICAL ACTIVITY IN AGING, OBESITY, AND CANCER
卷 1229, 期 -, 页码 29-37出版社
BLACKWELL SCIENCE PUBL
DOI: 10.1111/j.1749-6632.2011.06100.x
关键词
growth hormone; STAT5; liver function
资金
- NIH
- NRF [R33-10059]
- Rural Development Administration, Republic of Korea [PJ008191032011]
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [ZIADK061000] Funding Source: NIH RePORTER
The liver is a primary target of growth hormone (GH). GH signals arc mediated by the transcription factor signal transducer and activator of transcription 5 (STAT5). Here, we focus on recent discoveries about the role of GH-STAT5 signaling in hepatic physiology and pathophysiology. We discuss roles of the GH-STAT5 axis in body growth, lipid metabolism, and the cell cycle pertaining to hepatosteatosis, fibrosis, and hepatocellular carcinoma. Finally, we discuss recent discoveries about the role of GH-STAT5 in sex-specific gene expression and bile acid, steroid, and drug metabolism.
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