期刊
EVOLUTION OF INFECTIOUS AGENTS IN RELATION TO SEX
卷 1230, 期 -, 页码 48-58出版社
BLACKWELL SCIENCE PUBL
DOI: 10.1111/j.1749-6632.2011.06041.x
关键词
genital econiche; microbiota; bacterial vaginosis; evolution; biofilm development; immune tolerance; reproductive effects; sexual transmission
Ecological and evolutionary forces shaping the normal and abnormal microflora of the genital econiche are discussed, in particular those related to bacterial vaginosis, which worldwide is the most common vaginal infection, with numerous obstetrical and gynecological complications, including acquisition and transmission: of HIV and other sexually transmitted infections (STIs). Characterized by a heavy overgrowth of Gram-negative and Gram-positive anaerobes with no signs of inflammation, bacterial vaginosis has been regarded a microbiological and immunological enigma. Immune tolerance to both normal and abnormal vaginal microbiota, mainly derived from gut microflora, as a result of coevolution with humans might explain the absence of inflammation, supported by short-chain fatty acids, known to modulate immune responses, that are produced in large quantities by anaerobes. Recent studies have implicated the development of a vaginal biofilm with Gardnerella vaginalis and Atopobium vaginae as main players in the pathogenesis of bacterial vaginosis. Supporting this conclusion are data such as those demonstrating heavy growth of G. vaginalis and diversified anaerobes with numerous clue cells that are sloughing off from the biofilm. Gardnerella and Atopobium organisms attached to these clue cells can be demonstrated in the male genital econiche, likely reflecting a heterosexual transmission of the disorder.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据