期刊
NUTRITION AND PHYSICAL ACTIVITY IN AGING, OBESITY, AND CANCER
卷 1229, 期 -, 页码 140-146出版社
BLACKWELL SCIENCE PUBL
DOI: 10.1111/j.1749-6632.2011.06098.x
关键词
inflammation; obesity; metabolic disease; nutraceuticals
资金
- Korea Food Research Institute
- National Research Foundation, Korea
Obesity-induced inflammation plays an important role in the development of insulin resistance, type 2 diabetes (T2D), and metabolic dysfunctions. Chronic activation of proinflammatory pathways within insulin target cells can lead to obesity-related insulin resistance. The inflammatory mediators consist of immune cells, cytokines, adipokines, and inflammatory signaling molecules. Targeting obesity-associated inflammation has been shown to protect experimental animals and human subjects from obesity-induced insulin resistance. Modulation of the inflammatory responses associated with obesity may help prevent or improve obesity-induced metabolic dysfunctions. In this review, we introduce the beneficial effects of nutraceuticals for targeting inflammation in the treatment of obesity-induced insulin resistance and metabolic dysfunctions.
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