相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Evaluation of the lack of anorectic effect of intracerebroventricular insulin in rats
Lene Jessen et al.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2010)
Direct Insulin and Leptin Action on Pro-opiomelanocortin Neurons Is Required for Normal Glucose Homeostasis and Fertility
Jennifer W. Hill et al.
CELL METABOLISM (2010)
Diabetes regulates mitochondrial biogenesis and fission in mouse neurons
J. L. Edwards et al.
DIABETOLOGIA (2010)
Functional Role of c-Jun-N-Terminal Kinase in Feeding Regulation
Elizabeth K. Unger et al.
ENDOCRINOLOGY (2010)
Palmitate Attenuates Insulin Signaling and Induces Endoplasmic Reticulum Stress and Apoptosis in Hypothalamic Neurons: Rescue of Resistance and Apoptosis through Adenosine 5′ Monophosphate-Activated Protein Kinase Activation
Christopher M. Mayer et al.
ENDOCRINOLOGY (2010)
Leptin and the systems neuroscience of meal size control
Harvey J. Grill
FRONTIERS IN NEUROENDOCRINOLOGY (2010)
Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1
Guadalupe Sabio et al.
GENES & DEVELOPMENT (2010)
Disruption of hypothalamic leptin signaling in mice leads to early-onset obesity, but physiological adaptations in mature animals stabilize adiposity levels
Laurence E. Ring et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Leptin Excites Proopiomelanocortin Neurons via Activation of TRPC Channels
Jian Qiu et al.
JOURNAL OF NEUROSCIENCE (2010)
Segregation of Acute Leptin and Insulin Effects in Distinct Populations of Arcuate Proopiomelanocortin Neurons
Kevin W. Williams et al.
JOURNAL OF NEUROSCIENCE (2010)
The role of gut hormones in the regulation of body weight and energy homeostasis
Efthimia Karra et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2010)
Large, rare chromosomal deletions associated with severe early-onset obesity
Elena G. Bochukova et al.
NATURE (2010)
Pomc-expressing progenitors give rise to antagonistic neuronal populations in hypothalamic feeding circuits
Stephanie L. Padilla et al.
NATURE MEDICINE (2010)
Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism
Bengt F. Belgardt et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet
Kelly A. Posey et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2009)
Insulin blunts the response of glucose-excited neurons in the ventrolateral-ventromedial hypothalamic nucleus to decreased glucose
Victoria E. Cotero et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2009)
Insulin, leptin, and food reward: update 2008
Dianne P. Figlewicz et al.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2009)
Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells
Maria L. Watson et al.
BIOCHEMICAL JOURNAL (2009)
Loss of GABAergic Signaling by AgRP Neurons to the Parabrachial Nucleus Leads to Starvation
Qi Wu et al.
CELL (2009)
A Serotonin-Dependent Mechanism Explains the Leptin Regulation of Bone Mass, Appetite, and Energy Expenditure
Vijay K. Yadav et al.
CELL (2009)
MyD88 Signaling in the CNS Is Required for Development of Fatty Acid-Induced Leptin Resistance and Diet-Induced Obesity
Andre Kleinridders et al.
CELL METABOLISM (2009)
Dominant Role of the p110β Isoform of PI3K over p110α in Energy Homeostasis Regulation by POMC and AgRP Neurons
Hind Al-Qassab et al.
CELL METABOLISM (2009)
Leptin-Dependent Control of Glucose Balance and Locomotor Activity by POMC Neurons
Lihong Huo et al.
CELL METABOLISM (2009)
Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance
Lale Ozcan et al.
CELL METABOLISM (2009)
Leptin Acts via Leptin Receptor-Expressing Lateral Hypothalamic Neurons to Modulate the Mesolimbic Dopamine System and Suppress Feeding
Gina M. Leinninger et al.
CELL METABOLISM (2009)
Hypothalamic ERK Mediates the Anorectic and Thermogenic Sympathetic Effects of Leptin
Kamal Rahmouni et al.
DIABETES (2009)
Deletion of Tumor Necrosis Factor-α Receptor 1 (TNFR1) Protects against Diet-induced Obesity by Means of Increased Thermogenesis
Talita Romanatto et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Palmitic acid mediates hypothalamic insulin resistance by altering PKC-θ subcellular localization in rodents
Stephen C. Benoit et al.
JOURNAL OF CLINICAL INVESTIGATION (2009)
Leptin Targets in the Mouse Brain
Michael M. Scott et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2009)
Oleic Acid Directly Regulates POMC Neuron Excitability in the Hypothalamus
Young-Hwan Jo et al.
JOURNAL OF NEUROPHYSIOLOGY (2009)
Enhanced Stat3 Activation in POMC Neurons Provokes Negative Feedback Inhibition of Leptin and Insulin Signaling in Obesity
Marianne B. Ernst et al.
JOURNAL OF NEUROSCIENCE (2009)
Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity
Marciane Milanski et al.
JOURNAL OF NEUROSCIENCE (2009)
Hormone and glucose signalling in POMC and AgRP neurons
Bengt F. Belgardt et al.
JOURNAL OF PHYSIOLOGY-LONDON (2009)
Regulation of adaptive behaviour during fasting by hypothalamic Foxa2
Jose P. Silva et al.
NATURE (2009)
Inactivation of the Fto gene protects from obesity
Julia Fischer et al.
NATURE (2009)
The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake
Leona Plum et al.
NATURE MEDICINE (2009)
Molecular therapy of obesity and diabetes by a physiological autoregulatory approach
Lei Cao et al.
NATURE MEDICINE (2009)
Central Administration of an Endoplasmic Reticulum Stress Inducer Inhibits the Anorexigenic Effects of Leptin and Insulin
Jong Chul Won et al.
OBESITY (2009)
High-Fat Diet Induces Apoptosis of Hypothalamic Neurons
Juliana C. Moraes et al.
PLOS ONE (2009)
Hypothalamic IKKβ/NF-κB and ER stress link overnutrition to energy imbalance and obesity
Xiaoqing Zhang et al.
CELL (2008)
Activation of stat3 signaling in AgRP neurons promotes locomotor activity
Andrea Mesaros et al.
CELL METABOLISM (2008)
PDK1 deficiency in POMC-Expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response
Bengt F. Belgardt et al.
CELL METABOLISM (2008)
Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
Patrice D. Cani et al.
DIABETES (2008)
Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion
Esther Van de Wall et al.
ENDOCRINOLOGY (2008)
Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice
Jennifer W. Hill et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
Insulin sensitivity: modulation by nutrients and inflammation
Simon Schenk et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
Novel Leptin-Regulated Genes Revealed by Transcriptional Profiling of the Hypothalamic Paraventricular Nucleus
Yi-Chun Loraine Tung et al.
JOURNAL OF NEUROSCIENCE (2008)
Monitoring FoxO1 Localization in Chemically Identified Neurons
Makoto Fukuda et al.
JOURNAL OF NEUROSCIENCE (2008)
Adipokines and the peripheral and neural control of energy balance
Rexford S. Ahima et al.
MOLECULAR ENDOCRINOLOGY (2008)
Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms
Christoph Buettner et al.
NATURE MEDICINE (2008)
Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance
Qingchun Tong et al.
NATURE NEUROSCIENCE (2008)
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities
Inki Kim et al.
NATURE REVIEWS DRUG DISCOVERY (2008)
Glucose neurotoxicity
David R. Tomlinson et al.
NATURE REVIEWS NEUROSCIENCE (2008)
5-HT2CRs Expressed by Pro-Opiomelanocortin Neurons Regulate Energy Homeostasis
Yong Xu et al.
NEURON (2008)
Enhanced leptin-stimulated Pi3k activation in the CNS promotes white adipose tissue transdifferentiation
Leona Plum et al.
CELL METABOLISM (2007)
Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity
Laura E. Parton et al.
NATURE (2007)
AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons
Marc Claret et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production
A. Christine Koenner et al.
CELL METABOLISM (2007)
Variation in FTO contributes to childhood obesity and severe adult obesity
Christian Dina et al.
NATURE GENETICS (2007)
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance
William L. Holland et al.
CELL METABOLISM (2007)
Electrical inhibition of identified anorexigenic POMC neurons by orexin/hypocretin
Xiaosong Ma et al.
JOURNAL OF NEUROSCIENCE (2007)
Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals
Qian Gao et al.
NATURE MEDICINE (2007)
Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased Pomc expression, mild obesity, and defects in compensatory refeeding
Allison W. Xu et al.
ENDOCRINOLOGY (2007)
Intraventricular insulin and leptin reduce food intake and body weight in C57BL/6J mice
Lynda M. Brown et al.
PHYSIOLOGY & BEHAVIOR (2006)
TLR4 links innate immunity and fatty acid-induced insulin resistance
Hang Shi et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Leptin regulation of the mesoaccumbens dopamine pathway
Stephanie Fulton et al.
NEURON (2006)
Leptin receptor signaling in midbrain dopamine neurons regulates feeding
Jonathan D. Hommel et al.
NEURON (2006)
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
Umut Oezcan et al.
SCIENCE (2006)
Inducible-NOS but not neuronal-NOS participate in the acute effect of TNF-α on hypothalamic insulin-dependent inhibition of food intake
Juliana C. Moraes et al.
FEBS LETTERS (2006)
Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells
Paul Kievit et al.
CELL METABOLISM (2006)
gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor
Ruth Janoschek et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Central insulin action in energy and glucose homeostasis
Leona Plum et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity
Leona Plum et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis
Min-Seon Kim et al.
NATURE NEUROSCIENCE (2006)
A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic β-cells
Ke Ning et al.
EMBO JOURNAL (2006)
Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake
Tadahiro Kitamura et al.
NATURE MEDICINE (2006)
Induction of leptin resistance through direct interaction of C-reactive protein with leptin
K Chen et al.
NATURE MEDICINE (2006)
Insulin's direct effects on the liver dominate the control of hepatic glucose production
DS Edgerton et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis
H Dhillon et al.
NEURON (2006)
Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling
CD Morrison et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2005)
Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons
GJ Morton et al.
CELL METABOLISM (2005)
Astrocytes in the arcuate nucleus and median eminence that take up a fluorescent dye from the circulation express leptin receptors and neuropeptide YY1 receptors
O Cheunsuang et al.
GLIA (2005)
Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
S Cinti et al.
JOURNAL OF LIPID RESEARCH (2005)
Neurogenesis in the hypothalamus of adult mice: Potential role in energy balance
MV Kokoeva et al.
SCIENCE (2005)
NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates
S Luquet et al.
SCIENCE (2005)
Agouti-related peptide-expressing neurons are mandatory for feeding
[Anonymous]
NATURE NEUROSCIENCE (2005)
Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus
CT De Souza et al.
ENDOCRINOLOGY (2005)
Hypothalamic KATP channels control hepatic glucose production
A Pocai et al.
NATURE (2005)
Cytoplasmic protein tyrosine phosphatases, regulation and function:: the roles of PTP1B and TC-PTP
A Bourdeau et al.
CURRENT OPINION IN CELL BIOLOGY (2005)
The hypothalamic arcuate nucleus: A key site for mediating leptin's effects on glucose homeostasis and locomotor activity
R Coppari et al.
CELL METABOLISM (2005)
Leptin signaling targets the thyrotropin-releasing hormone gene promoter in vivo
FF Guo et al.
ENDOCRINOLOGY (2004)
The source of cerebral insulin
WA Banks
EUROPEAN JOURNAL OF PHARMACOLOGY (2004)
Rapid rewiring of arcuate nucleus feeding circuits by leptin
S Pinto et al.
SCIENCE (2004)
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
Y Minokoshi et al.
NATURE (2004)
Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system
W Fan et al.
NATURE NEUROSCIENCE (2004)
Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults
J Licinio et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis
A Tessitore et al.
MOLECULAR CELL (2004)
Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones:: PI3K dependent actin reorganization and KATP channel activation -: art. no. 54
S Mirshamsi et al.
BMC NEUROSCIENCE (2004)
Effects of lipopolysaccharide on leptin transport across the blood-brain barrier
N Nonaka et al.
BRAIN RESEARCH (2004)
Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity
H Mori et al.
NATURE MEDICINE (2004)
Leptin receptor signaling in is required for normal body POW neurons weight homeostasis
N Balthasar et al.
NEURON (2004)
Region-specific leptin resistance within the hypothalamus of diet-induced obese mice
H Münzberg et al.
ENDOCRINOLOGY (2004)
Intranasal insulin reduces body fat in men but not in women
M Hallschmid et al.
DIABETES (2004)
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
U Özcan et al.
SCIENCE (2004)
SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin
CJ Duan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Proopiomelanocortin and energy balance: Insights from human and murine genetics
AP Coll et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2004)
Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus
M van den Top et al.
NATURE NEUROSCIENCE (2004)
Triglycerides induce leptin resistance at the blood-brain barrier
WA Banks et al.
DIABETES (2004)
The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages
B Feng et al.
NATURE CELL BIOLOGY (2003)
Hypothalamic orexin neurons regulate arousal according to energy balance in mice
A Yamanaka et al.
NEURON (2003)
Expression of receptors for insulin and leptin in the ventral tegmental area/substantia nigra (VTA/SN) of the rat
DP Figlewicz et al.
BRAIN RESEARCH (2003)
Hypothalamic insulin signaling is required for inhibition of glucose production
S Obici et al.
NATURE MEDICINE (2002)
A central role for JNK in obesity and insulin resistance
J Hirosumi et al.
NATURE (2002)
SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2
LY Rui et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Brain stem is a direct target for leptin's action in the central nervous system
T Hosoi et al.
ENDOCRINOLOGY (2002)
Activation of central melanocortin pathways by fenfluramine
LK Heisler et al.
SCIENCE (2002)
Insulin and leptin combine additively to reduce food intake and body weight in rats
EL Air et al.
ENDOCRINOLOGY (2002)
PTP1B regulates leptin signal transduction in vivo
JM Zabolotny et al.
DEVELOPMENTAL CELL (2002)
Nucleotides and phospholipids compete for binding to the C terminus of KATP channels
GG MacGregor et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Knockout mice lacking steroidogenic factor 1 are a novel genetic model of hypothalamic obesity
G Majdic et al.
ENDOCRINOLOGY (2002)
Interleukin-6-deficient mice develop mature-onset obesity
V Wallenius et al.
NATURE MEDICINE (2002)
Ceramide mediates insulin resistance by tumor necrosis factor-α in brown adipocytes by maintaining Akt in an inactive dephosphorylated state
T Teruel et al.
DIABETES (2001)
Intracellular signalling - Key enzyme in leptin-induced anorexia
KD Niswender et al.
NATURE (2001)
A role for protein phosphatase 2A-like activity, but not atypical protein kinase Cζ, in the inhibition of protein kinase B/Akt and glycogen synthesis by palmitate
R Cazzolli et al.
DIABETES (2001)
Selective deletion of leptin receptor in neurons leads to obesity
P Cohen et al.
JOURNAL OF CLINICAL INVESTIGATION (2001)
Sim1 haploinsufficiency causes hyperphagia, obesity and reduction of the paraventricular nucleus of the hypothalamus
JL Michaud et al.
HUMAN MOLECULAR GENETICS (2001)
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
MA Cowley et al.
NATURE (2001)
Adiposity signals and the control of energy homeostasis
SC Woods et al.
NUTRITION (2000)
Role of brain insulin receptor in control of body weight and reproduction
JC Brüning et al.
SCIENCE (2000)
Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats
D Spanswick et al.
NATURE NEUROSCIENCE (2000)
Dopamine is required for hyperphagia in Lepob/ob mice
MS Szczypka et al.
NATURE GENETICS (2000)
分享论文
