期刊
YEAR IN IMMUNOLOGY
卷 1217, 期 -, 页码 83-95出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2010.05826.x
关键词
substance P; neurokinin-1 receptor; immunology
资金
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH049981, P01MH076388, U01MH090325] Funding Source: NIH RePORTER
- NIMH NIH HHS [R01 MH049981-15, U01 MH090325, R01 MH049981-12, P01-MH-076388, P01 MH076388-01, R01 MH049981-05, R01 MH049981, U01 MH090325-01, R01-MH-049981, R01 MH049981-16, U01 MH090325-02, P01 MH076388, U01-MH-090325, P01 MH076388-04] Funding Source: Medline
The G protein-coupled receptor (GPCR), neurokinin-1 receptor (NK1R), and its preferred ligand, substance P (SP), are reviewed in relationship to the immune system and selected infections. NK1R and SP are ubiquitous throughout the animal kingdom. This important pathway has unique functions in numerous cells and tissues. The interaction of SP with its preferred receptor, NK1R, leads to the activation of nuclear factor-kappa B (NF-kappa B) and proinflammatory cytokines. NK1R has two isoforms, both a full-length and a truncated form. These isoforms have different functional significances and differ in cell signaling capability. The proinflammatory signals modulated by SP are important in bacterial, viral, fungal, and parasitic diseases, as well as in immune system function. The SP-NK1R system is a major class 1, rhodopsin-like GPCR ligand-receptor interaction.
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