期刊
THYMOSINS IN HEALTH AND DISEASE
卷 1194, 期 -, 页码 179-189出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2010.05492.x
关键词
thymosin beta 4; tissue protection; tissue repair; tissue regeneration; apoptosis; inflammation; cell survival
Published studies have described a number of physiological properties and cellular functions of thymosin beta 4 (T beta 4), the major G-actin-sequestering molecule in mammalian cells. Those activities include the promotion of cell migration, blood vessel formation, cell survival, stem cell differentiation, the modulation of cytokines, chemokines, and specific proteases, the upregulation of matrix molecules and gene expression, and the downregulation of a major nuclear transcription factor. Such properties have provided the scientific rationale for a number of ongoing and planned dermal, corneal, cardiac clinical trials evaluating the tissue protective, regenerative and repair potential of T beta 4, and direction for future clinical applications in the treatment of diseases of the central nervous system, lung inflammatory disease, and sepsis. A special emphasis is placed on the development of T beta 4 in the treatment of patients with ST elevation myocardial infarction in combination with percutaneous coronary intervention.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据